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Tolbutamide Brand names, Tolbutamide Analogs

Tolbutamide Brand Names Mixture

  • No information avaliable

Tolbutamide Chemical_Formula


Tolbutamide RX_link

No information avaliable

Tolbutamide fda sheet

Tolbutamide msds (material safety sheet)

Tolbutamide MSDS

Tolbutamide Synthesis Reference

No information avaliable

Tolbutamide Molecular Weight

270.349 g/mol

Tolbutamide Melting Point

128.5 oC

Tolbutamide H2O Solubility

109 mg/L

Tolbutamide State


Tolbutamide LogP


Tolbutamide Dosage Forms

Tablet (250 and 500 mg)

Tolbutamide Indication

Used as an oral hypoglycemic agent in non-insulin-dependent (type 2) Diabetes Miletus with adult onset.

Tolbutamide Pharmacology

Tolbutamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Tolbutamide is twice as potent as the related second-generation agent glipizide. Tolbutamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must be able to produce insulin for this drug to work.

Tolbutamide Absorption

Well absorbed. Absorption is unaltered if taken with food but is increased with high pH.

Tolbutamide side effects and Toxicity

Oral, mouse: LD50 = 2600 mg/kg

Tolbutamide Patient Information

Treatment with tolbutamide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin. Discuss with your doctor the risks and benefits of treatment with tolbutamide. Know the signs and symptoms of low blood sugar (hypoglycemia), which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of hard candy or glucose tablets with you to treat episodes of low blood sugar. Follow your diet, medication, and exercise routines closely. Changing any of them can affect blood sugar levels. Do not change your dose of tolbutamide without first talking to your doctor. Avoid alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

Tolbutamide Organisms Affected

Humans and other mammals