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Orinase Brand names, Orinase Analogs

Orinase Brand Names Mixture

  • No information avaliable

Orinase Chemical_Formula


Orinase RX_link

No information avaliable

Orinase fda sheet

Orinase msds (material safety sheet)

Orinase MSDS

Orinase Synthesis Reference

No information avaliable

Orinase Molecular Weight

270.349 g/mol

Orinase Melting Point

128.5 oC

Orinase H2O Solubility

109 mg/L

Orinase State


Orinase LogP


Orinase Dosage Forms

Tablet (250 and 500 mg)

Orinase Indication

Used as an oral hypoglycemic agent in non-insulin-dependent (type 2) Diabetes Miletus with adult onset.

Orinase Pharmacology

Tolbutamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Tolbutamide is twice as potent as the related second-generation agent glipizide. Tolbutamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must be able to produce insulin for this drug to work.

Orinase Absorption

Well absorbed. Absorption is unaltered if taken with food but is increased with high pH.

Orinase side effects and Toxicity

Oral, mouse: LD50 = 2600 mg/kg

Orinase Patient Information

Treatment with tolbutamide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin. Discuss with your doctor the risks and benefits of treatment with tolbutamide. Know the signs and symptoms of low blood sugar (hypoglycemia), which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of hard candy or glucose tablets with you to treat episodes of low blood sugar. Follow your diet, medication, and exercise routines closely. Changing any of them can affect blood sugar levels. Do not change your dose of tolbutamide without first talking to your doctor. Avoid alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

Orinase Organisms Affected

Humans and other mammals