Drabet
Drabet Brand names, Drabet Analogs
- Aglicid
- Apo-Tolbutamide
- Arkozal
- Artosin
- Artozin
- Butamid
- Butamide
- Diaben
- Diabetamid
- Diabetol
- Diabuton
- Diasulfon
- Dirastan
- Dolipol
- Drabet
- Glyconon
- Ipoglicone
- Mobenol
- Novo-Butamide
- Orabet
- Oralin
- Orezan
- Orinase
- Orinase Diagnostic
- Orinaz
- Oterben
- Pramidex
- Rastinon
- Restinon
- Sk-tolbutamide
- Tol-Tab
- Tolbusal
- Tolbutamid
- Toluina
- Tolumid
- Toluvan
- Tolylsulfonylbutylurea
- Willbutamide
Drabet Brand Names Mixture
- No information avaliable
Drabet Chemical_Formula
C12H18N2O3S
Drabet RX_link
No information avaliable
Drabet fda sheet
Drabet msds (material safety sheet)
Drabet Synthesis Reference
No information avaliable
Drabet Molecular Weight
270.349 g/mol
Drabet Melting Point
128.5 oC
Drabet H2O Solubility
109 mg/L
Drabet State
Solid
Drabet LogP
2.765
Drabet Dosage Forms
Tablet (250 and 500 mg)
Drabet Indication
Used as an oral hypoglycemic agent in non-insulin-dependent (type 2) Diabetes Miletus with adult onset.
Drabet Pharmacology
Tolbutamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Tolbutamide is twice as potent as the related second-generation agent glipizide. Tolbutamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must be able to produce insulin for this drug to work.
Drabet Absorption
Well absorbed. Absorption is unaltered if taken with food but is increased with high pH.
Drabet side effects and Toxicity
Oral, mouse: LD50 = 2600 mg/kg
Drabet Patient Information
Treatment with tolbutamide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin. Discuss with your doctor the risks and benefits of treatment with tolbutamide. Know the signs and symptoms of low blood sugar (hypoglycemia), which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of hard candy or glucose tablets with you to treat episodes of low blood sugar. Follow your diet, medication, and exercise routines closely. Changing any of them can affect blood sugar levels. Do not change your dose of tolbutamide without first talking to your doctor. Avoid alcohol. It lowers blood sugar and may interfere with your diabetes treatment.
Drabet Organisms Affected
Humans and other mammals
