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Dirastan Brand names, Dirastan Analogs

Dirastan Brand Names Mixture

  • No information avaliable

Dirastan Chemical_Formula


Dirastan RX_link

No information avaliable

Dirastan fda sheet

Dirastan msds (material safety sheet)

Dirastan MSDS

Dirastan Synthesis Reference

No information avaliable

Dirastan Molecular Weight

270.349 g/mol

Dirastan Melting Point

128.5 oC

Dirastan H2O Solubility

109 mg/L

Dirastan State


Dirastan LogP


Dirastan Dosage Forms

Tablet (250 and 500 mg)

Dirastan Indication

Used as an oral hypoglycemic agent in non-insulin-dependent (type 2) Diabetes Miletus with adult onset.

Dirastan Pharmacology

Tolbutamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Tolbutamide is twice as potent as the related second-generation agent glipizide. Tolbutamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must be able to produce insulin for this drug to work.

Dirastan Absorption

Well absorbed. Absorption is unaltered if taken with food but is increased with high pH.

Dirastan side effects and Toxicity

Oral, mouse: LD50 = 2600 mg/kg

Dirastan Patient Information

Treatment with tolbutamide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin. Discuss with your doctor the risks and benefits of treatment with tolbutamide. Know the signs and symptoms of low blood sugar (hypoglycemia), which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of hard candy or glucose tablets with you to treat episodes of low blood sugar. Follow your diet, medication, and exercise routines closely. Changing any of them can affect blood sugar levels. Do not change your dose of tolbutamide without first talking to your doctor. Avoid alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

Dirastan Organisms Affected

Humans and other mammals