Tolylsulfonylbutylurea
Tolylsulfonylbutylurea Brand names, Tolylsulfonylbutylurea Analogs
- Aglicid
- Apo-Tolbutamide
- Arkozal
- Artosin
- Artozin
- Butamid
- Butamide
- Diaben
- Diabetamid
- Diabetol
- Diabuton
- Diasulfon
- Dirastan
- Dolipol
- Drabet
- Glyconon
- Ipoglicone
- Mobenol
- Novo-Butamide
- Orabet
- Oralin
- Orezan
- Orinase
- Orinase Diagnostic
- Orinaz
- Oterben
- Pramidex
- Rastinon
- Restinon
- Sk-tolbutamide
- Tol-Tab
- Tolbusal
- Tolbutamid
- Toluina
- Tolumid
- Toluvan
- Tolylsulfonylbutylurea
- Willbutamide
Tolylsulfonylbutylurea Brand Names Mixture
- No information avaliable
Tolylsulfonylbutylurea Chemical_Formula
C12H18N2O3S
Tolylsulfonylbutylurea RX_link
No information avaliable
Tolylsulfonylbutylurea fda sheet
Tolylsulfonylbutylurea msds (material safety sheet)
Tolylsulfonylbutylurea Synthesis Reference
No information avaliable
Tolylsulfonylbutylurea Molecular Weight
270.349 g/mol
Tolylsulfonylbutylurea Melting Point
128.5 oC
Tolylsulfonylbutylurea H2O Solubility
109 mg/L
Tolylsulfonylbutylurea State
Solid
Tolylsulfonylbutylurea LogP
2.765
Tolylsulfonylbutylurea Dosage Forms
Tablet (250 and 500 mg)
Tolylsulfonylbutylurea Indication
Used as an oral hypoglycemic agent in non-insulin-dependent (type 2) Diabetes Miletus with adult onset.
Tolylsulfonylbutylurea Pharmacology
Tolbutamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Tolbutamide is twice as potent as the related second-generation agent glipizide. Tolbutamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must be able to produce insulin for this drug to work.
Tolylsulfonylbutylurea Absorption
Well absorbed. Absorption is unaltered if taken with food but is increased with high pH.
Tolylsulfonylbutylurea side effects and Toxicity
Oral, mouse: LD50 = 2600 mg/kg
Tolylsulfonylbutylurea Patient Information
Treatment with tolbutamide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin. Discuss with your doctor the risks and benefits of treatment with tolbutamide. Know the signs and symptoms of low blood sugar (hypoglycemia), which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of hard candy or glucose tablets with you to treat episodes of low blood sugar. Follow your diet, medication, and exercise routines closely. Changing any of them can affect blood sugar levels. Do not change your dose of tolbutamide without first talking to your doctor. Avoid alcohol. It lowers blood sugar and may interfere with your diabetes treatment.
Tolylsulfonylbutylurea Organisms Affected
Humans and other mammals
