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Tolylsulfonylbutylurea Brand names, Tolylsulfonylbutylurea Analogs

Tolylsulfonylbutylurea Brand Names Mixture

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Tolylsulfonylbutylurea Chemical_Formula


Tolylsulfonylbutylurea RX_link

No information avaliable

Tolylsulfonylbutylurea fda sheet

Tolylsulfonylbutylurea msds (material safety sheet)

Tolylsulfonylbutylurea MSDS

Tolylsulfonylbutylurea Synthesis Reference

No information avaliable

Tolylsulfonylbutylurea Molecular Weight

270.349 g/mol

Tolylsulfonylbutylurea Melting Point

128.5 oC

Tolylsulfonylbutylurea H2O Solubility

109 mg/L

Tolylsulfonylbutylurea State


Tolylsulfonylbutylurea LogP


Tolylsulfonylbutylurea Dosage Forms

Tablet (250 and 500 mg)

Tolylsulfonylbutylurea Indication

Used as an oral hypoglycemic agent in non-insulin-dependent (type 2) Diabetes Miletus with adult onset.

Tolylsulfonylbutylurea Pharmacology

Tolbutamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Tolbutamide is twice as potent as the related second-generation agent glipizide. Tolbutamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must be able to produce insulin for this drug to work.

Tolylsulfonylbutylurea Absorption

Well absorbed. Absorption is unaltered if taken with food but is increased with high pH.

Tolylsulfonylbutylurea side effects and Toxicity

Oral, mouse: LD50 = 2600 mg/kg

Tolylsulfonylbutylurea Patient Information

Treatment with tolbutamide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin. Discuss with your doctor the risks and benefits of treatment with tolbutamide. Know the signs and symptoms of low blood sugar (hypoglycemia), which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of hard candy or glucose tablets with you to treat episodes of low blood sugar. Follow your diet, medication, and exercise routines closely. Changing any of them can affect blood sugar levels. Do not change your dose of tolbutamide without first talking to your doctor. Avoid alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

Tolylsulfonylbutylurea Organisms Affected

Humans and other mammals