Tiludronate
Tiludronate Brand names, Tiludronate Analogs
Tiludronate Brand Names Mixture
- No information avaliable
Tiludronate Chemical_Formula
C7H9ClO6P2S
Tiludronate RX_link
http://www.rxlist.com/cgi/generic2/tiludronate.htm
Tiludronate fda sheet
Tiludronate msds (material safety sheet)
Tiludronate Synthesis Reference
No information avaliable
Tiludronate Molecular Weight
318.609 g/mol
Tiludronate Melting Point
No information avaliable
Tiludronate H2O Solubility
No information avaliable
Tiludronate State
Solid
Tiludronate LogP
0.549
Tiludronate Dosage Forms
Tablets for oral administration containing 240 mg tiludronate disodium
Tiludronate Indication
For treatment of Paget's disease of bone (osteitis deformans).
Tiludronate Pharmacology
Tiludronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and clodronate. Tiludronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the tiludronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface.
Tiludronate Absorption
The mean oral bioavailability in healthy male subjects is 6% after an oral dose equivalent to 400 mg tiludronic acid administered after an overnight fast and 4 hours before a standard breakfast. In single-dose studies, bioavailability was reduced by 90% when an oral dose equivalent to 400 mg tiludronic acid was administered with, or 2 hours after, a standard breakfast compared to the same dose administered after an overnight fast and 4 hours before a standard breakfast.
Tiludronate side effects and Toxicity
Based on the known action of tiludronate, hypocalcemia is a potential consequence of overdose. In one patient with hypercalcemia of malignancy, intravenous administration of high doses (800 mg/day total dose, 6 mg/kg/day for 2 days) was associated with acute renal failure and death.
Tiludronate Patient Information
Tiludronate Organisms Affected
Humans and other mammals
