PharmacyCodes



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Micardis Brand names, Micardis Analogs

Micardis Brand Names Mixture

  • No information avaliable

Micardis Chemical_Formula

C7H9ClO6P2S

Micardis RX_link

http://www.rxlist.com/cgi/generic2/tiludronate.htm

Micardis fda sheet

Micardis msds (material safety sheet)

Micardis Synthesis Reference

No information avaliable

Micardis Molecular Weight

318.609 g/mol

Micardis Melting Point

No information avaliable

Micardis H2O Solubility

No information avaliable

Micardis State

Solid

Micardis LogP

0.549

Micardis Dosage Forms

Tablets for oral administration containing 240 mg tiludronate disodium

Micardis Indication

For treatment of Paget's disease of bone (osteitis deformans).

Micardis Pharmacology

Tiludronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and clodronate. Tiludronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the tiludronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface.

Micardis Absorption

The mean oral bioavailability in healthy male subjects is 6% after an oral dose equivalent to 400 mg tiludronic acid administered after an overnight fast and 4 hours before a standard breakfast. In single-dose studies, bioavailability was reduced by 90% when an oral dose equivalent to 400 mg tiludronic acid was administered with, or 2 hours after, a standard breakfast compared to the same dose administered after an overnight fast and 4 hours before a standard breakfast.

Micardis side effects and Toxicity

Based on the known action of tiludronate, hypocalcemia is a potential consequence of overdose. In one patient with hypercalcemia of malignancy, intravenous administration of high doses (800 mg/day total dose, 6 mg/kg/day for 2 days) was associated with acute renal failure and death.

Micardis Patient Information

Micardis Organisms Affected

Humans and other mammals