PharmacyCodes



BIBR 277 en es it fr

BIBR 277 Brand names, BIBR 277 Analogs

BIBR 277 Brand Names Mixture

  • No information avaliable

BIBR 277 Chemical_Formula

C7H9ClO6P2S

BIBR 277 RX_link

http://www.rxlist.com/cgi/generic2/tiludronate.htm

BIBR 277 fda sheet

BIBR 277 msds (material safety sheet)

BIBR 277 Synthesis Reference

No information avaliable

BIBR 277 Molecular Weight

318.609 g/mol

BIBR 277 Melting Point

No information avaliable

BIBR 277 H2O Solubility

No information avaliable

BIBR 277 State

Solid

BIBR 277 LogP

0.549

BIBR 277 Dosage Forms

Tablets for oral administration containing 240 mg tiludronate disodium

BIBR 277 Indication

For treatment of Paget's disease of bone (osteitis deformans).

BIBR 277 Pharmacology

Tiludronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and clodronate. Tiludronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the tiludronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface.

BIBR 277 Absorption

The mean oral bioavailability in healthy male subjects is 6% after an oral dose equivalent to 400 mg tiludronic acid administered after an overnight fast and 4 hours before a standard breakfast. In single-dose studies, bioavailability was reduced by 90% when an oral dose equivalent to 400 mg tiludronic acid was administered with, or 2 hours after, a standard breakfast compared to the same dose administered after an overnight fast and 4 hours before a standard breakfast.

BIBR 277 side effects and Toxicity

Based on the known action of tiludronate, hypocalcemia is a potential consequence of overdose. In one patient with hypercalcemia of malignancy, intravenous administration of high doses (800 mg/day total dose, 6 mg/kg/day for 2 days) was associated with acute renal failure and death.

BIBR 277 Patient Information

BIBR 277 Organisms Affected

Humans and other mammals