Thioridazine Monosulfoxide Analog
Thioridazine Monosulfoxide Analog Brand names, Thioridazine Monosulfoxide Analog Analogs
Thioridazine Monosulfoxide Analog Brand Names Mixture
- No information avaliable
Thioridazine Monosulfoxide Analog Chemical_Formula
C21H26N2OS2
Thioridazine Monosulfoxide Analog RX_link
http://www.rxlist.com/cgi/generic3/mesoridazine.htm
Thioridazine Monosulfoxide Analog fda sheet
Thioridazine Monosulfoxide Analog msds (material safety sheet)
Thioridazine Monosulfoxide Analog Synthesis Reference
No information avaliable
Thioridazine Monosulfoxide Analog Molecular Weight
386.576 g/mol
Thioridazine Monosulfoxide Analog Melting Point
No information avaliable
Thioridazine Monosulfoxide Analog H2O Solubility
No information avaliable
Thioridazine Monosulfoxide Analog State
Solid
Thioridazine Monosulfoxide Analog LogP
4.485
Thioridazine Monosulfoxide Analog Dosage Forms
Tablet (10 mg, 25 mg, 50 mg, 100 mg) for oral administration; Ampuls (1 mL) for intramuscular administration; Concentrate for oral administration
Thioridazine Monosulfoxide Analog Indication
Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses.
Thioridazine Monosulfoxide Analog Pharmacology
Mesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer. Pharmacological studies in laboratory animals have established that mesoridazine has a spectrum of pharmacodynamic actions typical of a major tranquilizer. In common with other tranquilizers it inhibits spontaneous motor activity in mice, prolongs thiopental and hexobarbital sleeping time in mice and produces spindles and block of arousal reaction in the EEG of rabbits. It is effective in blocking spinal reflexes in the cut and antagonizes d-amphetamine excitation and toxicity in grouped mice. It shows a moderate adrenergic blocking activity in vitro and in vivo and antagonizes 5-hydroxytryptamine in vivo. Intravenously administered, it lowers the blood pressure of anesthetized dogs. It has a weak antiacetylcholine effect in vitro.
Thioridazine Monosulfoxide Analog Absorption
Well absorbed from the gastrointestinal tract.
Thioridazine Monosulfoxide Analog side effects and Toxicity
Oral LD50 is 560 ± 62.5 mg/kg and 644 ± 48 mg/kg in mouse and rat, respectively. Symptoms of overdose may include emesis, muscle tremors, decreased food intake and death associated with aspiration of oral-gastric contents into the respiratory system.
Thioridazine Monosulfoxide Analog Patient Information
Thioridazine Monosulfoxide Analog Organisms Affected
Humans and other mammals
