PharmacyCodes



Lidanil en es it fr

Lidanil Brand names, Lidanil Analogs

Lidanil Brand Names Mixture

  • No information avaliable

Lidanil Chemical_Formula

C21H26N2OS2

Lidanil RX_link

http://www.rxlist.com/cgi/generic3/mesoridazine.htm

Lidanil fda sheet

Lidanil msds (material safety sheet)

Lidanil Synthesis Reference

No information avaliable

Lidanil Molecular Weight

386.576 g/mol

Lidanil Melting Point

No information avaliable

Lidanil H2O Solubility

No information avaliable

Lidanil State

Solid

Lidanil LogP

4.485

Lidanil Dosage Forms

Tablet (10 mg, 25 mg, 50 mg, 100 mg) for oral administration; Ampuls (1 mL) for intramuscular administration; Concentrate for oral administration

Lidanil Indication

Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses.

Lidanil Pharmacology

Mesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer. Pharmacological studies in laboratory animals have established that mesoridazine has a spectrum of pharmacodynamic actions typical of a major tranquilizer. In common with other tranquilizers it inhibits spontaneous motor activity in mice, prolongs thiopental and hexobarbital sleeping time in mice and produces spindles and block of arousal reaction in the EEG of rabbits. It is effective in blocking spinal reflexes in the cut and antagonizes d-amphetamine excitation and toxicity in grouped mice. It shows a moderate adrenergic blocking activity in vitro and in vivo and antagonizes 5-hydroxytryptamine in vivo. Intravenously administered, it lowers the blood pressure of anesthetized dogs. It has a weak antiacetylcholine effect in vitro.

Lidanil Absorption

Well absorbed from the gastrointestinal tract.

Lidanil side effects and Toxicity

Oral LD50 is 560 ± 62.5 mg/kg and 644 ± 48 mg/kg in mouse and rat, respectively. Symptoms of overdose may include emesis, muscle tremors, decreased food intake and death associated with aspiration of oral-gastric contents into the respiratory system.

Lidanil Patient Information

Lidanil Organisms Affected

Humans and other mammals