Thioridazien Thiomethyl Sulfoxide
Thioridazien Thiomethyl Sulfoxide Brand names, Thioridazien Thiomethyl Sulfoxide Analogs
Thioridazien Thiomethyl Sulfoxide Brand Names Mixture
- No information avaliable
Thioridazien Thiomethyl Sulfoxide Chemical_Formula
C21H26N2OS2
Thioridazien Thiomethyl Sulfoxide RX_link
http://www.rxlist.com/cgi/generic3/mesoridazine.htm
Thioridazien Thiomethyl Sulfoxide fda sheet
Thioridazien Thiomethyl Sulfoxide msds (material safety sheet)
Thioridazien Thiomethyl Sulfoxide Synthesis Reference
No information avaliable
Thioridazien Thiomethyl Sulfoxide Molecular Weight
386.576 g/mol
Thioridazien Thiomethyl Sulfoxide Melting Point
No information avaliable
Thioridazien Thiomethyl Sulfoxide H2O Solubility
No information avaliable
Thioridazien Thiomethyl Sulfoxide State
Solid
Thioridazien Thiomethyl Sulfoxide LogP
4.485
Thioridazien Thiomethyl Sulfoxide Dosage Forms
Tablet (10 mg, 25 mg, 50 mg, 100 mg) for oral administration; Ampuls (1 mL) for intramuscular administration; Concentrate for oral administration
Thioridazien Thiomethyl Sulfoxide Indication
Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses.
Thioridazien Thiomethyl Sulfoxide Pharmacology
Mesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer. Pharmacological studies in laboratory animals have established that mesoridazine has a spectrum of pharmacodynamic actions typical of a major tranquilizer. In common with other tranquilizers it inhibits spontaneous motor activity in mice, prolongs thiopental and hexobarbital sleeping time in mice and produces spindles and block of arousal reaction in the EEG of rabbits. It is effective in blocking spinal reflexes in the cut and antagonizes d-amphetamine excitation and toxicity in grouped mice. It shows a moderate adrenergic blocking activity in vitro and in vivo and antagonizes 5-hydroxytryptamine in vivo. Intravenously administered, it lowers the blood pressure of anesthetized dogs. It has a weak antiacetylcholine effect in vitro.
Thioridazien Thiomethyl Sulfoxide Absorption
Well absorbed from the gastrointestinal tract.
Thioridazien Thiomethyl Sulfoxide side effects and Toxicity
Oral LD50 is 560 ± 62.5 mg/kg and 644 ± 48 mg/kg in mouse and rat, respectively. Symptoms of overdose may include emesis, muscle tremors, decreased food intake and death associated with aspiration of oral-gastric contents into the respiratory system.
Thioridazien Thiomethyl Sulfoxide Patient Information
Thioridazien Thiomethyl Sulfoxide Organisms Affected
Humans and other mammals
