TPS23
TPS23 Brand names, TPS23 Analogs
TPS23 Brand Names Mixture
- No information avaliable
TPS23 Chemical_Formula
C21H26N2OS2
TPS23 RX_link
http://www.rxlist.com/cgi/generic3/mesoridazine.htm
TPS23 fda sheet
TPS23 msds (material safety sheet)
TPS23 Synthesis Reference
No information avaliable
TPS23 Molecular Weight
386.576 g/mol
TPS23 Melting Point
No information avaliable
TPS23 H2O Solubility
No information avaliable
TPS23 State
Solid
TPS23 LogP
4.485
TPS23 Dosage Forms
Tablet (10 mg, 25 mg, 50 mg, 100 mg) for oral administration; Ampuls (1 mL) for intramuscular administration; Concentrate for oral administration
TPS23 Indication
Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses.
TPS23 Pharmacology
Mesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer. Pharmacological studies in laboratory animals have established that mesoridazine has a spectrum of pharmacodynamic actions typical of a major tranquilizer. In common with other tranquilizers it inhibits spontaneous motor activity in mice, prolongs thiopental and hexobarbital sleeping time in mice and produces spindles and block of arousal reaction in the EEG of rabbits. It is effective in blocking spinal reflexes in the cut and antagonizes d-amphetamine excitation and toxicity in grouped mice. It shows a moderate adrenergic blocking activity in vitro and in vivo and antagonizes 5-hydroxytryptamine in vivo. Intravenously administered, it lowers the blood pressure of anesthetized dogs. It has a weak antiacetylcholine effect in vitro.
TPS23 Absorption
Well absorbed from the gastrointestinal tract.
TPS23 side effects and Toxicity
Oral LD50 is 560 ± 62.5 mg/kg and 644 ± 48 mg/kg in mouse and rat, respectively. Symptoms of overdose may include emesis, muscle tremors, decreased food intake and death associated with aspiration of oral-gastric contents into the respiratory system.
TPS23 Patient Information
TPS23 Organisms Affected
Humans and other mammals
