Testolactone
Testolactone Brand names, Testolactone Analogs
Testolactone Brand Names Mixture
- No information avaliable
Testolactone Chemical_Formula
C19H24O3
Testolactone RX_link
http://www.rxlist.com/cgi/generic2/testolactone.htm
Testolactone fda sheet
Testolactone msds (material safety sheet)
Testolactone Synthesis Reference
No information avaliable
Testolactone Molecular Weight
300.392 g/mol
Testolactone Melting Point
218.5 oC
Testolactone H2O Solubility
Slightly soluble (27.4 mg/L)
Testolactone State
Solid
Testolactone LogP
3.663
Testolactone Dosage Forms
For oral administration as tablets providing 50 mg testolactone per tablet
Testolactone Indication
For palliative treatment of advanced breast cancer in postmenopausal women.
Testolactone Pharmacology
Testolactone is a synthetic anti-neoplastic agent that is structurally distinct from the androgen steroid nucleus in possessing a six-membered lactone ring in place of the usual five-membered carbocyclic D-ring. Despite some similarity to testosterone, testolactone has no in vivo androgenic effect. No other hormonal effects have been reported in clinical studies in patients receiving testolactone.
Testolactone Absorption
Testolactone is well absorbed from the gastrointestinal tract.
Testolactone side effects and Toxicity
Oral LD50s in mouse and dog are 1630 mg/kg and 593-926 mg/kg, respectively.
Testolactone Patient Information
Testolactone Organisms Affected
Humans and other mammals
