Testolattone [Dcit]

Antineoplastic Agents, Hormonal

Testolattone [Dcit] Brand names, Testolattone [Dcit] Analogs

Testolattone [Dcit] Brand Names Mixture

No information avaliable

Testolattone [Dcit] Chemical_Formula

C₁₉H₂₄O₃

Testolattone [Dcit] RX_link

http://www.rxlist.com/cgi/generic2/testolactone.htm

Testolattone [Dcit] fda sheet

Testolattone_[Dcit] FDA

Testolattone [Dcit] msds (material safety sheet)

Testolattone_[Dcit] MSDS

Testolattone [Dcit] Synthesis Reference

No information avaliable

Testolattone [Dcit] Molecular Weight

300.392 g/mol

Testolattone [Dcit] Melting Point

218.5 ^oC

Testolattone [Dcit] H₂O Solubility

Slightly soluble (27.4 mg/L)

Testolattone [Dcit] State

Solid

Testolattone [Dcit] LogP

3.663

Testolattone [Dcit] Dosage Forms

For oral administration as tablets providing 50 mg testolactone per tablet

Testolattone [Dcit] Indication

For palliative treatment of advanced breast cancer in postmenopausal women.

Testolattone [Dcit] Pharmacology

Testolactone is a synthetic anti-neoplastic agent that is structurally distinct from the androgen steroid nucleus in possessing a six-membered lactone ring in place of the usual five-membered carbocyclic D-ring. Despite some similarity to testosterone, testolactone has no in vivo androgenic effect. No other hormonal effects have been reported in clinical studies in patients receiving testolactone.

Testolattone [Dcit] Absorption

Testolactone is well absorbed from the gastrointestinal tract.

Testolattone [Dcit] side effects and Toxicity

Oral LD₅₀s in mouse and dog are 1630 mg/kg and 593-926 mg/kg, respectively.

Testolattone [Dcit] Patient Information

Testolattone [Dcit] Organisms Affected

Humans and other mammals