Testolacton
Testolacton Brand names, Testolacton Analogs
Testolacton Brand Names Mixture
- No information avaliable
Testolacton Chemical_Formula
C19H24O3
Testolacton RX_link
http://www.rxlist.com/cgi/generic2/testolactone.htm
Testolacton fda sheet
Testolacton msds (material safety sheet)
Testolacton Synthesis Reference
No information avaliable
Testolacton Molecular Weight
300.392 g/mol
Testolacton Melting Point
218.5 oC
Testolacton H2O Solubility
Slightly soluble (27.4 mg/L)
Testolacton State
Solid
Testolacton LogP
3.663
Testolacton Dosage Forms
For oral administration as tablets providing 50 mg testolactone per tablet
Testolacton Indication
For palliative treatment of advanced breast cancer in postmenopausal women.
Testolacton Pharmacology
Testolactone is a synthetic anti-neoplastic agent that is structurally distinct from the androgen steroid nucleus in possessing a six-membered lactone ring in place of the usual five-membered carbocyclic D-ring. Despite some similarity to testosterone, testolactone has no in vivo androgenic effect. No other hormonal effects have been reported in clinical studies in patients receiving testolactone.
Testolacton Absorption
Testolactone is well absorbed from the gastrointestinal tract.
Testolacton side effects and Toxicity
Oral LD50s in mouse and dog are 1630 mg/kg and 593-926 mg/kg, respectively.
Testolacton Patient Information
Testolacton Organisms Affected
Humans and other mammals
