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Targret Brand names, Targret Analogs

Targret Brand Names Mixture

  • No information avaliable

Targret Chemical_Formula

C24H28O2

Targret RX_link

http://www.rxlist.com/cgi/generic3/bexarotene.htm

Targret fda sheet

Targret FDA

Targret msds (material safety sheet)

Targret Synthesis Reference

No information avaliable

Targret Molecular Weight

348.478 g/mol

Targret Melting Point

No information avaliable

Targret H2O Solubility

No information avaliable

Targret State

Solid

Targret LogP

8.096

Targret Dosage Forms

No information avaliable

Targret Indication

For the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy

Targret Pharmacology

Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs). Bexarotene is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy. Bexarotene selectively binds and activates retinoid X receptor subtypes (RXRa, RXRb, RXRg). RXRs can form heterodimers with various receptor partners such as retinoic acid receptors (RARs), vitamin Dy receptor, thyroid receptor, and peroxisome proliferator activator receptors (PPARs). Once activated, these receptors function as transcription factors that regulate the expression of genes that control cellular differentiation and proliferation. Bexarotene inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin. It also induces tumor regression in vivo in some animal models.

Targret Absorption

No information avaliable

Targret side effects and Toxicity

No information avaliable

Targret Patient Information

No information avaliable

Targret Organisms Affected

Humans and other mammals