Targret
Targret Brand names, Targret Analogs
Targret Brand Names Mixture
- No information avaliable
Targret Chemical_Formula
C24H28O2
Targret RX_link
http://www.rxlist.com/cgi/generic3/bexarotene.htm
Targret fda sheet
Targret msds (material safety sheet)
Targret Synthesis Reference
No information avaliable
Targret Molecular Weight
348.478 g/mol
Targret Melting Point
No information avaliable
Targret H2O Solubility
No information avaliable
Targret State
Solid
Targret LogP
8.096
Targret Dosage Forms
No information avaliable
Targret Indication
For the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy
Targret Pharmacology
Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs). Bexarotene is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy. Bexarotene selectively binds and activates retinoid X receptor subtypes (RXRa, RXRb, RXRg). RXRs can form heterodimers with various receptor partners such as retinoic acid receptors (RARs), vitamin Dy receptor, thyroid receptor, and peroxisome proliferator activator receptors (PPARs). Once activated, these receptors function as transcription factors that regulate the expression of genes that control cellular differentiation and proliferation. Bexarotene inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin. It also induces tumor regression in vivo in some animal models.
Targret Absorption
No information avaliable
Targret side effects and Toxicity
No information avaliable
Targret Patient Information
No information avaliable
Targret Organisms Affected
Humans and other mammals
