Targretin en es it fr

Targretin Brand names, Targretin Analogs

Targretin Brand Names Mixture

  • No information avaliable

Targretin Chemical_Formula

C24H28O2

Targretin RX_link

http://www.rxlist.com/cgi/generic3/bexarotene.htm

Targretin fda sheet

Targretin FDA

Targretin msds (material safety sheet)

Targretin Synthesis Reference

No information avaliable

Targretin Molecular Weight

348.478 g/mol

Targretin Melting Point

No information avaliable

Targretin H2O Solubility

No information avaliable

Targretin State

Solid

Targretin LogP

8.096

Targretin Dosage Forms

No information avaliable

Targretin Indication

For the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy

Targretin Pharmacology

Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs). Bexarotene is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy. Bexarotene selectively binds and activates retinoid X receptor subtypes (RXRa, RXRb, RXRg). RXRs can form heterodimers with various receptor partners such as retinoic acid receptors (RARs), vitamin Dy receptor, thyroid receptor, and peroxisome proliferator activator receptors (PPARs). Once activated, these receptors function as transcription factors that regulate the expression of genes that control cellular differentiation and proliferation. Bexarotene inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin. It also induces tumor regression in vivo in some animal models.

Targretin Absorption

No information avaliable

Targretin side effects and Toxicity

No information avaliable

Targretin Patient Information

No information avaliable

Targretin Organisms Affected

Humans and other mammals