Targretin
Targretin Brand names, Targretin Analogs
Targretin Brand Names Mixture
- No information avaliable
Targretin Chemical_Formula
C24H28O2
Targretin RX_link
http://www.rxlist.com/cgi/generic3/bexarotene.htm
Targretin fda sheet
Targretin msds (material safety sheet)
Targretin Synthesis Reference
No information avaliable
Targretin Molecular Weight
348.478 g/mol
Targretin Melting Point
No information avaliable
Targretin H2O Solubility
No information avaliable
Targretin State
Solid
Targretin LogP
8.096
Targretin Dosage Forms
No information avaliable
Targretin Indication
For the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy
Targretin Pharmacology
Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs). Bexarotene is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy. Bexarotene selectively binds and activates retinoid X receptor subtypes (RXRa, RXRb, RXRg). RXRs can form heterodimers with various receptor partners such as retinoic acid receptors (RARs), vitamin Dy receptor, thyroid receptor, and peroxisome proliferator activator receptors (PPARs). Once activated, these receptors function as transcription factors that regulate the expression of genes that control cellular differentiation and proliferation. Bexarotene inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin. It also induces tumor regression in vivo in some animal models.
Targretin Absorption
No information avaliable
Targretin side effects and Toxicity
No information avaliable
Targretin Patient Information
No information avaliable
Targretin Organisms Affected
Humans and other mammals
