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Targrexin Brand names, Targrexin Analogs

Targrexin Brand Names Mixture

  • No information avaliable

Targrexin Chemical_Formula

C24H28O2

Targrexin RX_link

http://www.rxlist.com/cgi/generic3/bexarotene.htm

Targrexin fda sheet

Targrexin FDA

Targrexin msds (material safety sheet)

Targrexin Synthesis Reference

No information avaliable

Targrexin Molecular Weight

348.478 g/mol

Targrexin Melting Point

No information avaliable

Targrexin H2O Solubility

No information avaliable

Targrexin State

Solid

Targrexin LogP

8.096

Targrexin Dosage Forms

No information avaliable

Targrexin Indication

For the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy

Targrexin Pharmacology

Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs). Bexarotene is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy. Bexarotene selectively binds and activates retinoid X receptor subtypes (RXRa, RXRb, RXRg). RXRs can form heterodimers with various receptor partners such as retinoic acid receptors (RARs), vitamin Dy receptor, thyroid receptor, and peroxisome proliferator activator receptors (PPARs). Once activated, these receptors function as transcription factors that regulate the expression of genes that control cellular differentiation and proliferation. Bexarotene inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin. It also induces tumor regression in vivo in some animal models.

Targrexin Absorption

No information avaliable

Targrexin side effects and Toxicity

No information avaliable

Targrexin Patient Information

No information avaliable

Targrexin Organisms Affected

Humans and other mammals