Targrexin
Targrexin Brand names, Targrexin Analogs
Targrexin Brand Names Mixture
- No information avaliable
Targrexin Chemical_Formula
C24H28O2
Targrexin RX_link
http://www.rxlist.com/cgi/generic3/bexarotene.htm
Targrexin fda sheet
Targrexin msds (material safety sheet)
Targrexin Synthesis Reference
No information avaliable
Targrexin Molecular Weight
348.478 g/mol
Targrexin Melting Point
No information avaliable
Targrexin H2O Solubility
No information avaliable
Targrexin State
Solid
Targrexin LogP
8.096
Targrexin Dosage Forms
No information avaliable
Targrexin Indication
For the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy
Targrexin Pharmacology
Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs). Bexarotene is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy. Bexarotene selectively binds and activates retinoid X receptor subtypes (RXRa, RXRb, RXRg). RXRs can form heterodimers with various receptor partners such as retinoic acid receptors (RARs), vitamin Dy receptor, thyroid receptor, and peroxisome proliferator activator receptors (PPARs). Once activated, these receptors function as transcription factors that regulate the expression of genes that control cellular differentiation and proliferation. Bexarotene inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin. It also induces tumor regression in vivo in some animal models.
Targrexin Absorption
No information avaliable
Targrexin side effects and Toxicity
No information avaliable
Targrexin Patient Information
No information avaliable
Targrexin Organisms Affected
Humans and other mammals
