Targretyn
Targretyn Brand names, Targretyn Analogs
Targretyn Brand Names Mixture
- No information avaliable
Targretyn Chemical_Formula
C24H28O2
Targretyn RX_link
http://www.rxlist.com/cgi/generic3/bexarotene.htm
Targretyn fda sheet
Targretyn msds (material safety sheet)
Targretyn Synthesis Reference
No information avaliable
Targretyn Molecular Weight
348.478 g/mol
Targretyn Melting Point
No information avaliable
Targretyn H2O Solubility
No information avaliable
Targretyn State
Solid
Targretyn LogP
8.096
Targretyn Dosage Forms
No information avaliable
Targretyn Indication
For the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy
Targretyn Pharmacology
Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs). Bexarotene is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy. Bexarotene selectively binds and activates retinoid X receptor subtypes (RXRa, RXRb, RXRg). RXRs can form heterodimers with various receptor partners such as retinoic acid receptors (RARs), vitamin Dy receptor, thyroid receptor, and peroxisome proliferator activator receptors (PPARs). Once activated, these receptors function as transcription factors that regulate the expression of genes that control cellular differentiation and proliferation. Bexarotene inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin. It also induces tumor regression in vivo in some animal models.
Targretyn Absorption
No information avaliable
Targretyn side effects and Toxicity
No information avaliable
Targretyn Patient Information
No information avaliable
Targretyn Organisms Affected
Humans and other mammals
