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Bexarotene [Usan] en es it fr

Bexarotene [Usan] Brand names, Bexarotene [Usan] Analogs

Bexarotene [Usan] Brand Names Mixture

  • No information avaliable

Bexarotene [Usan] Chemical_Formula

C24H28O2

Bexarotene [Usan] RX_link

http://www.rxlist.com/cgi/generic3/bexarotene.htm

Bexarotene [Usan] fda sheet

Bexarotene_[Usan] FDA

Bexarotene [Usan] msds (material safety sheet)

Bexarotene [Usan] Synthesis Reference

No information avaliable

Bexarotene [Usan] Molecular Weight

348.478 g/mol

Bexarotene [Usan] Melting Point

No information avaliable

Bexarotene [Usan] H2O Solubility

No information avaliable

Bexarotene [Usan] State

Solid

Bexarotene [Usan] LogP

8.096

Bexarotene [Usan] Dosage Forms

No information avaliable

Bexarotene [Usan] Indication

For the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy

Bexarotene [Usan] Pharmacology

Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs). Bexarotene is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy. Bexarotene selectively binds and activates retinoid X receptor subtypes (RXRa, RXRb, RXRg). RXRs can form heterodimers with various receptor partners such as retinoic acid receptors (RARs), vitamin Dy receptor, thyroid receptor, and peroxisome proliferator activator receptors (PPARs). Once activated, these receptors function as transcription factors that regulate the expression of genes that control cellular differentiation and proliferation. Bexarotene inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin. It also induces tumor regression in vivo in some animal models.

Bexarotene [Usan] Absorption

No information avaliable

Bexarotene [Usan] side effects and Toxicity

No information avaliable

Bexarotene [Usan] Patient Information

No information avaliable

Bexarotene [Usan] Organisms Affected

Humans and other mammals