Streptozocin

Streptozocin Brand names, Streptozocin Analogs

Streptozocin Brand Names Mixture

No information avaliable

Streptozocin Chemical_Formula

C₈H₁₅N₃O₇

Streptozocin RX_link

http://www.rxlist.com/cgi/generic/zanosar.htm

Streptozocin fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=215

Streptozocin msds (material safety sheet)

Streptozocin Synthesis Reference

No information avaliable

Streptozocin Molecular Weight

265.221 g/mol

Streptozocin Melting Point

115 ^oC

Streptozocin H₂O Solubility

5070 mg/L

Streptozocin State

Solid

Streptozocin LogP

-2.958

Streptozocin Dosage Forms

Powder for solution

Streptozocin Indication

For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).

Streptozocin Pharmacology

Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. Streptozocin is indicated in the treatment of metastatic islet cell carcinoma of the pancreas. Streptozocin inhibits DNA synthesis in bacterial and mammalian cells. In bacterial cells, a specific interaction with cytosine moieties leads to degradation of DNA. The biochemical mechanism leading to mammalian cell death has not been definitely established; streptozocin inhibits cell proliferation at a considerably lower level than that needed to inhibit precursor incorporation into DNA or to inhibit several of the enzymes involved in DNA synthesis. Although streptozocin inhibits the progression of cells into mitosis, no specific phase of the cell cycle is particularly sensitive to its lethal effects.

Streptozocin Absorption

Poor oral absorption (17-25%)

Streptozocin side effects and Toxicity

Symptoms of overdose include nausea and vomiting, anorexia, myelosuppression; and nephrotoxicity.

Streptozocin Patient Information