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STZ Brand names, STZ Analogs

STZ Brand Names Mixture

  • No information avaliable

STZ Chemical_Formula


STZ RX_link

STZ fda sheet

STZ msds (material safety sheet)

STZ Synthesis Reference

No information avaliable

STZ Molecular Weight

265.221 g/mol

STZ Melting Point

115 oC

STZ H2O Solubility

5070 mg/L

STZ State




STZ Dosage Forms

Powder for solution

STZ Indication

For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).

STZ Pharmacology

Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. Streptozocin is indicated in the treatment of metastatic islet cell carcinoma of the pancreas. Streptozocin inhibits DNA synthesis in bacterial and mammalian cells. In bacterial cells, a specific interaction with cytosine moieties leads to degradation of DNA. The biochemical mechanism leading to mammalian cell death has not been definitely established; streptozocin inhibits cell proliferation at a considerably lower level than that needed to inhibit precursor incorporation into DNA or to inhibit several of the enzymes involved in DNA synthesis. Although streptozocin inhibits the progression of cells into mitosis, no specific phase of the cell cycle is particularly sensitive to its lethal effects.

STZ Absorption

Poor oral absorption (17-25%)

STZ side effects and Toxicity

Symptoms of overdose include nausea and vomiting, anorexia, myelosuppression; and nephrotoxicity.

STZ Patient Information

No information avaliable

STZ Organisms Affected

Humans and other mammals