STREPTOZOTOCIN

STREPTOZOTOCIN Brand names, STREPTOZOTOCIN Analogs

STREPTOZOTOCIN Brand Names Mixture

No information avaliable

STREPTOZOTOCIN Chemical_Formula

C₈H₁₅N₃O₇

STREPTOZOTOCIN RX_link

http://www.rxlist.com/cgi/generic/zanosar.htm

STREPTOZOTOCIN fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=215

STREPTOZOTOCIN msds (material safety sheet)

STREPTOZOTOCIN Synthesis Reference

No information avaliable

STREPTOZOTOCIN Molecular Weight

265.221 g/mol

STREPTOZOTOCIN Melting Point

115 ^oC

STREPTOZOTOCIN H₂O Solubility

5070 mg/L

STREPTOZOTOCIN State

Solid

STREPTOZOTOCIN LogP

-2.958

STREPTOZOTOCIN Dosage Forms

Powder for solution

STREPTOZOTOCIN Indication

For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).

STREPTOZOTOCIN Pharmacology

Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. Streptozocin is indicated in the treatment of metastatic islet cell carcinoma of the pancreas. Streptozocin inhibits DNA synthesis in bacterial and mammalian cells. In bacterial cells, a specific interaction with cytosine moieties leads to degradation of DNA. The biochemical mechanism leading to mammalian cell death has not been definitely established; streptozocin inhibits cell proliferation at a considerably lower level than that needed to inhibit precursor incorporation into DNA or to inhibit several of the enzymes involved in DNA synthesis. Although streptozocin inhibits the progression of cells into mitosis, no specific phase of the cell cycle is particularly sensitive to its lethal effects.

STREPTOZOTOCIN Absorption

Poor oral absorption (17-25%)

STREPTOZOTOCIN side effects and Toxicity

Symptoms of overdose include nausea and vomiting, anorexia, myelosuppression; and nephrotoxicity.

STREPTOZOTOCIN Patient Information