Streptozoticin en es it fr

Streptozoticin Brand names, Streptozoticin Analogs

Streptozoticin Brand Names Mixture

  • No information avaliable

Streptozoticin Chemical_Formula


Streptozoticin RX_link

Streptozoticin fda sheet

Streptozoticin msds (material safety sheet)

Streptozoticin Synthesis Reference

No information avaliable

Streptozoticin Molecular Weight

265.221 g/mol

Streptozoticin Melting Point

115 oC

Streptozoticin H2O Solubility

5070 mg/L

Streptozoticin State


Streptozoticin LogP


Streptozoticin Dosage Forms

Powder for solution

Streptozoticin Indication

For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).

Streptozoticin Pharmacology

Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. Streptozocin is indicated in the treatment of metastatic islet cell carcinoma of the pancreas. Streptozocin inhibits DNA synthesis in bacterial and mammalian cells. In bacterial cells, a specific interaction with cytosine moieties leads to degradation of DNA. The biochemical mechanism leading to mammalian cell death has not been definitely established; streptozocin inhibits cell proliferation at a considerably lower level than that needed to inhibit precursor incorporation into DNA or to inhibit several of the enzymes involved in DNA synthesis. Although streptozocin inhibits the progression of cells into mitosis, no specific phase of the cell cycle is particularly sensitive to its lethal effects.

Streptozoticin Absorption

Poor oral absorption (17-25%)

Streptozoticin side effects and Toxicity

Symptoms of overdose include nausea and vomiting, anorexia, myelosuppression; and nephrotoxicity.

Streptozoticin Patient Information

No information avaliable

Streptozoticin Organisms Affected

Humans and other mammals