Streptozocinum [Inn-Latin] en es it fr

Streptozocinum [Inn-Latin] Brand names, Streptozocinum [Inn-Latin] Analogs

Streptozocinum [Inn-Latin] Brand Names Mixture

  • No information avaliable

Streptozocinum [Inn-Latin] Chemical_Formula


Streptozocinum [Inn-Latin] RX_link

Streptozocinum [Inn-Latin] fda sheet

Streptozocinum [Inn-Latin] msds (material safety sheet)

Streptozocinum [Inn-Latin] Synthesis Reference

No information avaliable

Streptozocinum [Inn-Latin] Molecular Weight

265.221 g/mol

Streptozocinum [Inn-Latin] Melting Point

115 oC

Streptozocinum [Inn-Latin] H2O Solubility

5070 mg/L

Streptozocinum [Inn-Latin] State


Streptozocinum [Inn-Latin] LogP


Streptozocinum [Inn-Latin] Dosage Forms

Powder for solution

Streptozocinum [Inn-Latin] Indication

For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).

Streptozocinum [Inn-Latin] Pharmacology

Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. Streptozocin is indicated in the treatment of metastatic islet cell carcinoma of the pancreas. Streptozocin inhibits DNA synthesis in bacterial and mammalian cells. In bacterial cells, a specific interaction with cytosine moieties leads to degradation of DNA. The biochemical mechanism leading to mammalian cell death has not been definitely established; streptozocin inhibits cell proliferation at a considerably lower level than that needed to inhibit precursor incorporation into DNA or to inhibit several of the enzymes involved in DNA synthesis. Although streptozocin inhibits the progression of cells into mitosis, no specific phase of the cell cycle is particularly sensitive to its lethal effects.

Streptozocinum [Inn-Latin] Absorption

Poor oral absorption (17-25%)

Streptozocinum [Inn-Latin] side effects and Toxicity

Symptoms of overdose include nausea and vomiting, anorexia, myelosuppression; and nephrotoxicity.

Streptozocinum [Inn-Latin] Patient Information

No information avaliable

Streptozocinum [Inn-Latin] Organisms Affected

Humans and other mammals