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Spirolone Brand names, Spirolone Analogs

Spirolone Brand Names Mixture

  • No information avaliable

Spirolone Chemical_Formula


Spirolone RX_link


Spirolone fda sheet

Spirolone FDA

Spirolone msds (material safety sheet)

Spirolone MSDS

Spirolone Synthesis Reference

No information avaliable

Spirolone Molecular Weight

514.617 g/mol

Spirolone Melting Point


Spirolone H2O Solubility

Practically insoluble

Spirolone State


Spirolone LogP


Spirolone Dosage Forms


Spirolone Indication

For the treatment of hypertension.

Spirolone Pharmacology

Telmisartan is an orally active nonpeptide angiotensin II antagonist that acts on the AT1 receptor subtype. New studies suggest that telmisartan may also have PPARγ agonistic properties that could potentially confer beneficial metabolic effects. This observation is currently being explored in clinical trials. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Telmisartan works by blocking the vasoconstrictor and aldosterone secretory effects of angiotensin II.

Spirolone Absorption

Absolute bioavailability depends on dosage. Food slightly decreases the bioavailability (a decrease of about 6% is seen when the 40-mg dose is administered with food).

Spirolone side effects and Toxicity

Intravenous LD50 in rats is 150-200 mg/kg in males and 200 to 250 mg/kg in females. Acute oral toxicity is low: no deaths and no changes occurred in rats or dogs at 2000 mg/kg, the highest dose tested. Limited data are available with regard to overdosage in humans. The most likely manifestations of overdosage with telmisartan would be hypotension, dizziness and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation.

Spirolone Patient Information

Spirolone Organisms Affected

Humans and other mammals