Spiroctan en es it fr

Spiroctan Brand names, Spiroctan Analogs

Spiroctan Brand Names Mixture

  • No information avaliable

Spiroctan Chemical_Formula


Spiroctan RX_link


Spiroctan fda sheet

Spiroctan FDA

Spiroctan msds (material safety sheet)

Spiroctan MSDS

Spiroctan Synthesis Reference

No information avaliable

Spiroctan Molecular Weight

514.617 g/mol

Spiroctan Melting Point


Spiroctan H2O Solubility

Practically insoluble

Spiroctan State


Spiroctan LogP


Spiroctan Dosage Forms


Spiroctan Indication

For the treatment of hypertension.

Spiroctan Pharmacology

Telmisartan is an orally active nonpeptide angiotensin II antagonist that acts on the AT1 receptor subtype. New studies suggest that telmisartan may also have PPARγ agonistic properties that could potentially confer beneficial metabolic effects. This observation is currently being explored in clinical trials. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Telmisartan works by blocking the vasoconstrictor and aldosterone secretory effects of angiotensin II.

Spiroctan Absorption

Absolute bioavailability depends on dosage. Food slightly decreases the bioavailability (a decrease of about 6% is seen when the 40-mg dose is administered with food).

Spiroctan side effects and Toxicity

Intravenous LD50 in rats is 150-200 mg/kg in males and 200 to 250 mg/kg in females. Acute oral toxicity is low: no deaths and no changes occurred in rats or dogs at 2000 mg/kg, the highest dose tested. Limited data are available with regard to overdosage in humans. The most likely manifestations of overdosage with telmisartan would be hypotension, dizziness and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation.

Spiroctan Patient Information

Spiroctan Organisms Affected

Humans and other mammals