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Spirolactone Brand names, Spirolactone Analogs

Spirolactone Brand Names Mixture

  • No information avaliable

Spirolactone Chemical_Formula


Spirolactone RX_link


Spirolactone fda sheet

Spirolactone FDA

Spirolactone msds (material safety sheet)

Spirolactone MSDS

Spirolactone Synthesis Reference

No information avaliable

Spirolactone Molecular Weight

514.617 g/mol

Spirolactone Melting Point


Spirolactone H2O Solubility

Practically insoluble

Spirolactone State


Spirolactone LogP


Spirolactone Dosage Forms


Spirolactone Indication

For the treatment of hypertension.

Spirolactone Pharmacology

Telmisartan is an orally active nonpeptide angiotensin II antagonist that acts on the AT1 receptor subtype. New studies suggest that telmisartan may also have PPARγ agonistic properties that could potentially confer beneficial metabolic effects. This observation is currently being explored in clinical trials. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Telmisartan works by blocking the vasoconstrictor and aldosterone secretory effects of angiotensin II.

Spirolactone Absorption

Absolute bioavailability depends on dosage. Food slightly decreases the bioavailability (a decrease of about 6% is seen when the 40-mg dose is administered with food).

Spirolactone side effects and Toxicity

Intravenous LD50 in rats is 150-200 mg/kg in males and 200 to 250 mg/kg in females. Acute oral toxicity is low: no deaths and no changes occurred in rats or dogs at 2000 mg/kg, the highest dose tested. Limited data are available with regard to overdosage in humans. The most likely manifestations of overdosage with telmisartan would be hypotension, dizziness and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation.

Spirolactone Patient Information

Spirolactone Organisms Affected

Humans and other mammals