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Dira Brand names, Dira Analogs

Dira Brand Names Mixture

  • No information avaliable

Dira Chemical_Formula


Dira RX_link

No information avaliable

Dira fda sheet

Dira msds (material safety sheet)


Dira Synthesis Reference

No information avaliable

Dira Molecular Weight

270.349 g/mol

Dira Melting Point

128.5 oC

Dira H2O Solubility

109 mg/L

Dira State


Dira LogP


Dira Dosage Forms

Tablet (250 and 500 mg)

Dira Indication

Used as an oral hypoglycemic agent in non-insulin-dependent (type 2) Diabetes Miletus with adult onset.

Dira Pharmacology

Tolbutamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Tolbutamide is twice as potent as the related second-generation agent glipizide. Tolbutamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must be able to produce insulin for this drug to work.

Dira Absorption

Well absorbed. Absorption is unaltered if taken with food but is increased with high pH.

Dira side effects and Toxicity

Oral, mouse: LD50 = 2600 mg/kg

Dira Patient Information

Treatment with tolbutamide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin. Discuss with your doctor the risks and benefits of treatment with tolbutamide. Know the signs and symptoms of low blood sugar (hypoglycemia), which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of hard candy or glucose tablets with you to treat episodes of low blood sugar. Follow your diet, medication, and exercise routines closely. Changing any of them can affect blood sugar levels. Do not change your dose of tolbutamide without first talking to your doctor. Avoid alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

Dira Organisms Affected

Humans and other mammals