Spiridon
Brand names,
Spiridon
Analogs
Spiridon
Brand Names Mixture
Spiridon
Chemical_Formula
C33H30N4O2
Spiridon
RX_link
http://www.rxlist.com/cgi/generic2/telmisartan.htm
Spiridon
fda sheet
Spiridon
msds (material safety sheet)
Spiridon
Synthesis Reference
No information avaliable
Spiridon
Molecular Weight
514.617 g/mol
Spiridon
Melting Point
261-263oC
Spiridon
H2O Solubility
Practically insoluble
Spiridon
State
Solid
Spiridon
LogP
7.245
Spiridon
Dosage Forms
Tablets
Spiridon
Indication
For the treatment of hypertension.
Spiridon
Pharmacology
Telmisartan is an orally active nonpeptide angiotensin II antagonist that acts on the AT1 receptor subtype. New studies suggest that telmisartan may also have PPARĪ³ agonistic properties that could potentially confer beneficial metabolic effects. This observation is currently being explored in clinical trials. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Telmisartan works by blocking the vasoconstrictor and aldosterone secretory effects of angiotensin II.
Spiridon
Absorption
Absolute bioavailability depends on dosage. Food slightly decreases the bioavailability (a decrease of about 6% is seen when the 40-mg dose is administered with food).
Spiridon
side effects and Toxicity
Intravenous LD50 in rats is 150-200 mg/kg in males and 200 to 250 mg/kg in females. Acute oral toxicity is low: no deaths and no changes occurred in rats or dogs at 2000 mg/kg, the highest dose tested. Limited data are available with regard to overdosage in humans. The most likely manifestations of overdosage with telmisartan would be hypotension, dizziness and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation.
Spiridon
Patient Information
Spiridon
Organisms Affected
Humans and other mammals