Sincurarine
Brand names,
Sincurarine
Analogs
Sincurarine
Brand Names Mixture
Sincurarine
Chemical_Formula
C24H45N3O3
Sincurarine
RX_link
No information avaliable
Sincurarine
fda sheet
Sincurarine
msds (material safety sheet)
Sincurarine
Synthesis Reference
No information avaliable
Sincurarine
Molecular Weight
423.633 g/mol
Sincurarine
Melting Point
147.5 oC
Sincurarine
H2O Solubility
Soluble
Sincurarine
State
Solid
Sincurarine
LogP
4.017
Sincurarine
Dosage Forms
Liquid
Sincurarine
Indication
For use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation
Sincurarine
Pharmacology
Gallamine Triethiodide is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. Muscle groups differ in their sensitivity to these types of relaxants with ocular muscles (controlling eyelids) being most sensitive, followed by the muscles of the neck, jaw, limbs and then abdomen. The diaphragm is the least sensitive muscle to NDMRDs. Although the nondepolarizing neuromuscular blocking drugs do not have the same adverse effects as succinylcholine, their onset of action is slower. They also have a longer duration of action, making them more suitable for maintaining neuromuscular relaxation during major surgical procedures.
Sincurarine
Absorption
No information avaliable
Sincurarine
side effects and Toxicity
No information avaliable
Sincurarine
Patient Information
No information avaliable
Sincurarine
Organisms Affected
Humans and other mammals