Sevofluranum [INN-Latin]

Sevofluranum [INN-Latin] Brand names, Sevofluranum [INN-Latin] Analogs

Sevofluranum [INN-Latin] Brand Names Mixture

No information avaliable

Sevofluranum [INN-Latin] Chemical_Formula

C₄H₃F₇O

Sevofluranum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic2/sevoflurane.htm

Sevofluranum [INN-Latin] fda sheet

Sevofluranum_[INN-Latin] FDA

Sevofluranum [INN-Latin] msds (material safety sheet)

Sevofluranum_[INN-Latin] MSDS

Sevofluranum [INN-Latin] Synthesis Reference

No information avaliable

Sevofluranum [INN-Latin] Molecular Weight

200.055 g/mol

Sevofluranum [INN-Latin] Melting Point

< 25°C (boiling point: 58.6°C)

Sevofluranum [INN-Latin] H₂O Solubility

Very slightly soluble

Sevofluranum [INN-Latin] State

Liquid

Sevofluranum [INN-Latin] LogP

2.212

Sevofluranum [INN-Latin] Dosage Forms

Liquid (in a canister, to be vaporized for inhalation)

Sevofluranum [INN-Latin] Indication

Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Sevofluranum [INN-Latin] Pharmacology

Sevoflurane (also called fluoromethyl) is a halogenated ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. It is often administered in nitrous oxide and pure oxygen. After desflurane it is the volatile anesthetic with the fastest onset and offset. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.

Sevofluranum [INN-Latin] Absorption

Rapidly absorbed into circulation via the lungs, however solubility in the blood is low.

Sevofluranum [INN-Latin] side effects and Toxicity

LC50=49881 ppm/hr (rat), LD₅₀=10.8 g/kg (rat)

Sevofluranum [INN-Latin] Patient Information