Sevoflurano [INN-Spanish]

Sevoflurano [INN-Spanish] Brand names, Sevoflurano [INN-Spanish] Analogs

Sevoflurano [INN-Spanish] Brand Names Mixture

No information avaliable

Sevoflurano [INN-Spanish] Chemical_Formula

C₄H₃F₇O

Sevoflurano [INN-Spanish] RX_link

http://www.rxlist.com/cgi/generic2/sevoflurane.htm

Sevoflurano [INN-Spanish] fda sheet

Sevoflurano_[INN-Spanish] FDA

Sevoflurano [INN-Spanish] msds (material safety sheet)

Sevoflurano_[INN-Spanish] MSDS

Sevoflurano [INN-Spanish] Synthesis Reference

No information avaliable

Sevoflurano [INN-Spanish] Molecular Weight

200.055 g/mol

Sevoflurano [INN-Spanish] Melting Point

< 25°C (boiling point: 58.6°C)

Sevoflurano [INN-Spanish] H₂O Solubility

Very slightly soluble

Sevoflurano [INN-Spanish] State

Liquid

Sevoflurano [INN-Spanish] LogP

2.212

Sevoflurano [INN-Spanish] Dosage Forms

Liquid (in a canister, to be vaporized for inhalation)

Sevoflurano [INN-Spanish] Indication

Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Sevoflurano [INN-Spanish] Pharmacology

Sevoflurane (also called fluoromethyl) is a halogenated ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. It is often administered in nitrous oxide and pure oxygen. After desflurane it is the volatile anesthetic with the fastest onset and offset. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.

Sevoflurano [INN-Spanish] Absorption

Rapidly absorbed into circulation via the lungs, however solubility in the blood is low.

Sevoflurano [INN-Spanish] side effects and Toxicity

LC50=49881 ppm/hr (rat), LD₅₀=10.8 g/kg (rat)

Sevoflurano [INN-Spanish] Patient Information