Sevofluran

Sevofluran Brand names, Sevofluran Analogs

Sevofluran Brand Names Mixture

No information avaliable

Sevofluran Chemical_Formula

C₄H₃F₇O

Sevofluran RX_link

http://www.rxlist.com/cgi/generic2/sevoflurane.htm

Sevofluran fda sheet

Sevofluran FDA

Sevofluran msds (material safety sheet)

Sevofluran MSDS

Sevofluran Synthesis Reference

No information avaliable

Sevofluran Molecular Weight

200.055 g/mol

Sevofluran Melting Point

< 25°C (boiling point: 58.6°C)

Sevofluran H₂O Solubility

Very slightly soluble

Sevofluran State

Liquid

Sevofluran LogP

2.212

Sevofluran Dosage Forms

Liquid (in a canister, to be vaporized for inhalation)

Sevofluran Indication

Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Sevofluran Pharmacology

Sevoflurane (also called fluoromethyl) is a halogenated ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. It is often administered in nitrous oxide and pure oxygen. After desflurane it is the volatile anesthetic with the fastest onset and offset. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.

Sevofluran Absorption

Rapidly absorbed into circulation via the lungs, however solubility in the blood is low.

Sevofluran side effects and Toxicity

LC50=49881 ppm/hr (rat), LD₅₀=10.8 g/kg (rat)

Sevofluran Patient Information