Sevoflurane

Sevoflurane Brand names, Sevoflurane Analogs

Sevoflurane Brand Names Mixture

No information avaliable

Sevoflurane Chemical_Formula

C₄H₃F₇O

Sevoflurane RX_link

http://www.rxlist.com/cgi/generic2/sevoflurane.htm

Sevoflurane fda sheet

Sevoflurane FDA

Sevoflurane msds (material safety sheet)

Sevoflurane MSDS

Sevoflurane Synthesis Reference

No information avaliable

Sevoflurane Molecular Weight

200.055 g/mol

Sevoflurane Melting Point

< 25°C (boiling point: 58.6°C)

Sevoflurane H₂O Solubility

Very slightly soluble

Sevoflurane State

Liquid

Sevoflurane LogP

2.212

Sevoflurane Dosage Forms

Liquid (in a canister, to be vaporized for inhalation)

Sevoflurane Indication

Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Sevoflurane Pharmacology

Sevoflurane (also called fluoromethyl) is a halogenated ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. It is often administered in nitrous oxide and pure oxygen. After desflurane it is the volatile anesthetic with the fastest onset and offset. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.

Sevoflurane Absorption

Rapidly absorbed into circulation via the lungs, however solubility in the blood is low.

Sevoflurane side effects and Toxicity

LC50=49881 ppm/hr (rat), LD₅₀=10.8 g/kg (rat)

Sevoflurane Patient Information