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Ritonavir Brand names, Ritonavir Analogs

Ritonavir Brand Names Mixture

  • Kaletra (Lopinavir + Ritonavir)

Ritonavir Chemical_Formula


Ritonavir RX_link


Ritonavir fda sheet

Ritonavir FDA

Ritonavir msds (material safety sheet)

Ritonavir MSDS

Ritonavir Synthesis Reference

No information avaliable

Ritonavir Molecular Weight

720.946 g/mol

Ritonavir Melting Point

No information avaliable

Ritonavir H2O Solubility

Practically insoluble

Ritonavir State


Ritonavir LogP


Ritonavir Dosage Forms

Capsule (100 mg); Solution (80 mg/mL of ritonavir)

Ritonavir Indication

Indicated in combination with other antiretroviral agents for the treatment of HIV-infection.

Ritonavir Pharmacology

Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Ritonavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.

Ritonavir Absorption

The absolute bioavailability of ritonavir has not been determined.

Ritonavir side effects and Toxicity

Human experience of acute overdose with NORVIR is limited. One patient in clinical trials took NORVIR 1500 mg/day for two days. The patient reported paresthesias which resolved after the dose was decreased. A post-marketing case of renal failure with eosinophilia has been reported with ritonavir overdose. The approximate lethal dose was found to be greater than 20 times the related human dose in rats and 10 times the related human dose in mice.

Ritonavir Patient Information

No information avaliable

Ritonavir Organisms Affected

Human immunodeficiency virus