Ritodrinium [Inn-Latin]
Brand names,
Ritodrinium [Inn-Latin]
Analogs
Ritodrinium [Inn-Latin]
Brand Names Mixture
Ritodrinium [Inn-Latin]
Chemical_Formula
C17H21NO3
Ritodrinium [Inn-Latin]
RX_link
No information avaliable
Ritodrinium [Inn-Latin]
fda sheet
Ritodrinium [Inn-Latin]
msds (material safety sheet)
Ritodrinium [Inn-Latin]
Synthesis Reference
Belg. pat. 660.244 (1965 to N.V. Philips), C.A. 63, 17965h (1965) corresp to Claassen et al., U.S. pat. 3,410,944 (1968 to No. Am. Philips)
Ritodrinium [Inn-Latin]
Molecular Weight
287.354 g/mol
Ritodrinium [Inn-Latin]
Melting Point
88-90 oC
Ritodrinium [Inn-Latin]
H2O Solubility
Complete
Ritodrinium [Inn-Latin]
State
Solid
Ritodrinium [Inn-Latin]
LogP
2.588
Ritodrinium [Inn-Latin]
Dosage Forms
Solution for IV; Capsule (extended-release); Tablet; Intramuscular injection
Ritodrinium [Inn-Latin]
Indication
For the treatment and prophylaxis of premature labour
Ritodrinium [Inn-Latin]
Pharmacology
Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Ritodrine is beta-2 adrenergic agonist. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle.
Ritodrinium [Inn-Latin]
Absorption
No information avaliable
Ritodrinium [Inn-Latin]
side effects and Toxicity
LD50=64mg/kg (mice, IV); LD50=540 mg/kg (mice, oral); LD50=85 mg/kg (rat, IV)
Ritodrinium [Inn-Latin]
Patient Information
Ritodrinium [Inn-Latin]
Organisms Affected
Humans and other mammals