Periactinol
Brand names,
Periactinol
Analogs
Periactinol
Brand Names Mixture
Periactinol
Chemical_Formula
C21H21N
Periactinol
RX_link
http://www.rxlist.com/cgi/generic2/cyprohept.htm
Periactinol
fda sheet
Periactinol
msds (material safety sheet)
Periactinol
Synthesis Reference
No information avaliable
Periactinol
Molecular Weight
287.398 g/mol
Periactinol
Melting Point
215-217 oC
Periactinol
H2O Solubility
Soluble
Periactinol
State
Solid
Periactinol
LogP
4.682
Periactinol
Dosage Forms
Syrup; Tablet
Periactinol
Indication
For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine.
Periactinol
Pharmacology
Cyproheptadine is a piperidine antihistamine. Unlike other antihistamines, this drug also antagonizes serotonin receptors. This action makes Cyproheptadine useful in conditions such as vascular headache and anorexia. Cyproheptadine does not prevent the release of histamine but rather competes with free histamine for binding at HA-receptor sites. Cyproheptadine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. Most antihistamines possess significant anticholinergic properties, but Cyproheptadine exerts only weak anticholinergic actions. Blockade of central muscarinic receptors appears to account for Cyproheptadine's antiemetic effects, although the exact mechanism is unknown. Cyproheptadine also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations. Antagonism of serotonin on the appetite center of the hypothalamus may account for Cyproheptadine's ability to stimulate appetite. Cyproheptadine also has been used to counter vascular headaches, which many believe are caused by changes in serotonin activity, however it is unclear how Cyproheptadine exerts a beneficial effect on this condition.
Periactinol
Absorption
Well absorbed after oral administration.
Periactinol
side effects and Toxicity
No information avaliable
Periactinol
Patient Information
Antihistamines may diminish mental alertness; conversely, particularly, in the young child, they may occasionally
produce excitation. Patients should be warned about engaging in activities requiring mental alertness and motor
coordination, such as driving a car or operating machinery.
Periactinol
Organisms Affected
Humans and other mammals