Dibenzosuberonone/Cyproheptadine
Dibenzosuberonone/Cyproheptadine Brand names, Dibenzosuberonone/Cyproheptadine Analogs
Dibenzosuberonone/Cyproheptadine Brand Names Mixture
- No information avaliable
Dibenzosuberonone/Cyproheptadine Chemical_Formula
C21H21N
Dibenzosuberonone/Cyproheptadine RX_link
http://www.rxlist.com/cgi/generic2/cyprohept.htm
Dibenzosuberonone/Cyproheptadine fda sheet
Dibenzosuberonone/Cyproheptadine msds (material safety sheet)
Dibenzosuberonone/Cyproheptadine Synthesis Reference
No information avaliable
Dibenzosuberonone/Cyproheptadine Molecular Weight
287.398 g/mol
Dibenzosuberonone/Cyproheptadine Melting Point
215-217 oC
Dibenzosuberonone/Cyproheptadine H2O Solubility
Soluble
Dibenzosuberonone/Cyproheptadine State
Solid
Dibenzosuberonone/Cyproheptadine LogP
4.682
Dibenzosuberonone/Cyproheptadine Dosage Forms
Syrup; Tablet
Dibenzosuberonone/Cyproheptadine Indication
For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine.
Dibenzosuberonone/Cyproheptadine Pharmacology
Cyproheptadine is a piperidine antihistamine. Unlike other antihistamines, this drug also antagonizes serotonin receptors. This action makes Cyproheptadine useful in conditions such as vascular headache and anorexia. Cyproheptadine does not prevent the release of histamine but rather competes with free histamine for binding at HA-receptor sites. Cyproheptadine competitively antagonizes the effects of histamine on HA-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. Most antihistamines possess significant anticholinergic properties, but Cyproheptadine exerts only weak anticholinergic actions. Blockade of central muscarinic receptors appears to account for Cyproheptadine's antiemetic effects, although the exact mechanism is unknown. Cyproheptadine also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations. Antagonism of serotonin on the appetite center of the hypothalamus may account for Cyproheptadine's ability to stimulate appetite. Cyproheptadine also has been used to counter vascular headaches, which many believe are caused by changes in serotonin activity, however it is unclear how Cyproheptadine exerts a beneficial effect on this condition.
Dibenzosuberonone/Cyproheptadine Absorption
Well absorbed after oral administration.
Dibenzosuberonone/Cyproheptadine side effects and Toxicity
No information avaliable
Dibenzosuberonone/Cyproheptadine Patient Information
Antihistamines may diminish mental alertness; conversely, particularly, in the young child, they may occasionally produce excitation. Patients should be warned about engaging in activities requiring mental alertness and motor coordination, such as driving a car or operating machinery.
Dibenzosuberonone/Cyproheptadine Organisms Affected
Humans and other mammals
