Novopyrazone
Brand names,
Novopyrazone
Analogs
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Brand Names Mixture
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Chemical_Formula
C23H20N2O3S
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RX_link
http://www.rxlist.com/cgi/generic3/sulfinpyrazone.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
404.483 g/mol
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Melting Point
136-137 oC
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H2O Solubility
31.2 mg/L
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State
Solid
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LogP
3.015
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Dosage Forms
100-mg tablets and 200-mg capsules for oral administration
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Indication
For the treatment of gout and gouty arthritis.
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Pharmacology
Sulfinpyrazone's pharmacologic activity is the potentiation of the urinary excretion of uric acid. It is useful for reducing the blood urate levels in patients with chronic tophaceous gout and acute intermittent gout, and for promoting the resorption of tophi.
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Absorption
No information avaliable
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side effects and Toxicity
Symptoms of overdose include nausea, vomiting, diarrhea, epigastric pain, ataxia, labored respiration, convulsions, coma. Possible symptoms, seen after overdosage with other pyrazolone derivatives: anemia, jaundice, and ulceration.
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals