Nizatidine
Nizatidine Brand names, Nizatidine Analogs
Nizatidine Brand Names Mixture
- No information avaliable
Nizatidine Chemical_Formula
C12H21N5O2S2
Nizatidine RX_link
http://www.rxlist.com/cgi/generic/nizat.htm
Nizatidine fda sheet
Nizatidine msds (material safety sheet)
Nizatidine Synthesis Reference
R. P. Pioch, U.S. Pat. 4,375,547 (1982)
Nizatidine Molecular Weight
331.46 g/mol
Nizatidine Melting Point
203 oC
Nizatidine H2O Solubility
10-33mg/mL
Nizatidine State
Solid
Nizatidine LogP
1.506
Nizatidine Dosage Forms
Capsule (150, 300 mg)
Nizatidine Indication
For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer.
Nizatidine Pharmacology
Nizatidine is a competitive, reversible inhibitor of histamine at the histamine H2-receptors, particularly those in the gastric parietal cells. By inhibiting the action of histamine on stomach cells, nizatidine reduces stomach acid production. Nizatidine had no demonstrable antiandrogenic action. Full-dose therapy for the problems treated by nizatidine lasts no longer than 8 weeks. It has been demonstrated that treatment with a reduced dose of nizatidine is effective as maintenance therapy following healing of active duodenal ulcers.
Nizatidine Absorption
Rapid (bioavailability of nizatidine exceeds 70%)
Nizatidine side effects and Toxicity
Oral, rat LD50: 301 mg/kg. Symptoms of overdose include cholinergic-type effects including lacrimation, salivation, emesis, miosis, and diarrhea.
Nizatidine Patient Information
Nizatidine Organisms Affected
Humans and other mammals
