Distaxid
Distaxid Brand names, Distaxid Analogs
Distaxid Brand Names Mixture
- No information avaliable
Distaxid Chemical_Formula
C12H21N5O2S2
Distaxid RX_link
http://www.rxlist.com/cgi/generic/nizat.htm
Distaxid fda sheet
Distaxid msds (material safety sheet)
Distaxid Synthesis Reference
R. P. Pioch, U.S. Pat. 4,375,547 (1982)
Distaxid Molecular Weight
331.46 g/mol
Distaxid Melting Point
203 oC
Distaxid H2O Solubility
10-33mg/mL
Distaxid State
Solid
Distaxid LogP
1.506
Distaxid Dosage Forms
Capsule (150, 300 mg)
Distaxid Indication
For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer.
Distaxid Pharmacology
Nizatidine is a competitive, reversible inhibitor of histamine at the histamine H2-receptors, particularly those in the gastric parietal cells. By inhibiting the action of histamine on stomach cells, nizatidine reduces stomach acid production. Nizatidine had no demonstrable antiandrogenic action. Full-dose therapy for the problems treated by nizatidine lasts no longer than 8 weeks. It has been demonstrated that treatment with a reduced dose of nizatidine is effective as maintenance therapy following healing of active duodenal ulcers.
Distaxid Absorption
Rapid (bioavailability of nizatidine exceeds 70%)
Distaxid side effects and Toxicity
Oral, rat LD50: 301 mg/kg. Symptoms of overdose include cholinergic-type effects including lacrimation, salivation, emesis, miosis, and diarrhea.
Distaxid Patient Information
Distaxid Organisms Affected
Humans and other mammals
