Axid Ar
Axid Ar Brand names, Axid Ar Analogs
Axid Ar Brand Names Mixture
- No information avaliable
Axid Ar Chemical_Formula
C12H21N5O2S2
Axid Ar RX_link
http://www.rxlist.com/cgi/generic/nizat.htm
Axid Ar fda sheet
Axid Ar msds (material safety sheet)
Axid Ar Synthesis Reference
R. P. Pioch, U.S. Pat. 4,375,547 (1982)
Axid Ar Molecular Weight
331.46 g/mol
Axid Ar Melting Point
203 oC
Axid Ar H2O Solubility
10-33mg/mL
Axid Ar State
Solid
Axid Ar LogP
1.506
Axid Ar Dosage Forms
Capsule (150, 300 mg)
Axid Ar Indication
For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer.
Axid Ar Pharmacology
Nizatidine is a competitive, reversible inhibitor of histamine at the histamine H2-receptors, particularly those in the gastric parietal cells. By inhibiting the action of histamine on stomach cells, nizatidine reduces stomach acid production. Nizatidine had no demonstrable antiandrogenic action. Full-dose therapy for the problems treated by nizatidine lasts no longer than 8 weeks. It has been demonstrated that treatment with a reduced dose of nizatidine is effective as maintenance therapy following healing of active duodenal ulcers.
Axid Ar Absorption
Rapid (bioavailability of nizatidine exceeds 70%)
Axid Ar side effects and Toxicity
Oral, rat LD50: 301 mg/kg. Symptoms of overdose include cholinergic-type effects including lacrimation, salivation, emesis, miosis, and diarrhea.
Axid Ar Patient Information
Axid Ar Organisms Affected
Humans and other mammals
