Axid
Axid Brand names, Axid Analogs
Axid Brand Names Mixture
- No information avaliable
Axid Chemical_Formula
C12H21N5O2S2
Axid RX_link
http://www.rxlist.com/cgi/generic/nizat.htm
Axid fda sheet
Axid msds (material safety sheet)
Axid Synthesis Reference
R. P. Pioch, U.S. Pat. 4,375,547 (1982)
Axid Molecular Weight
331.46 g/mol
Axid Melting Point
203 oC
Axid H2O Solubility
10-33mg/mL
Axid State
Solid
Axid LogP
1.506
Axid Dosage Forms
Capsule (150, 300 mg)
Axid Indication
For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer.
Axid Pharmacology
Nizatidine is a competitive, reversible inhibitor of histamine at the histamine H2-receptors, particularly those in the gastric parietal cells. By inhibiting the action of histamine on stomach cells, nizatidine reduces stomach acid production. Nizatidine had no demonstrable antiandrogenic action. Full-dose therapy for the problems treated by nizatidine lasts no longer than 8 weeks. It has been demonstrated that treatment with a reduced dose of nizatidine is effective as maintenance therapy following healing of active duodenal ulcers.
Axid Absorption
Rapid (bioavailability of nizatidine exceeds 70%)
Axid side effects and Toxicity
Oral, rat LD50: 301 mg/kg. Symptoms of overdose include cholinergic-type effects including lacrimation, salivation, emesis, miosis, and diarrhea.
Axid Patient Information
Axid Organisms Affected
Humans and other mammals
