Nicoderm Cq
Brand names,
Nicoderm Cq
Analogs
Nicoderm Cq
Brand Names Mixture
Nicoderm Cq
Chemical_Formula
C10H14N2
Nicoderm Cq
RX_link
http://www.rxlist.com/cgi/generic2/nicotini.htm
Nicoderm Cq
fda sheet
Nicoderm Cq
msds (material safety sheet)
Nicoderm Cq
Synthesis Reference
Pinner, Ber. 26, 294 (1893)
Nicoderm Cq
Molecular Weight
162.232 g/mol
Nicoderm Cq
Melting Point
-79 oC
Nicoderm Cq
H2O Solubility
1 g/mL
Nicoderm Cq
State
Liquid
Nicoderm Cq
LogP
1.305
Nicoderm Cq
Dosage Forms
Gum; Inhaler; Patch
Nicoderm Cq
Indication
For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Nicoderm Cq
Pharmacology
Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia.
Nicoderm Cq
Absorption
Absorption of nicotine through the buccal mucosa is relatively slow and the high and rapid rise followed by the decline in nicotine arterial plasma concentrations seen with cigarette smoking are not achieved with the inhaler. About 10% of absorbed nicotine is excreted unchanged in urine.
Nicoderm Cq
side effects and Toxicity
Symptoms of overdose include nausea, abdominal pain, vomiting, diarrhea, diaphoresis, flushing, dizziness, disturbed hearing and vision, confusion, weakness, palpitations, altered respiration and hypotension. LD50= 24 mg/kg (orally in mice).
Nicoderm Cq
Patient Information
A patient information sheet is included in the package of NICOTROL Inhaler cartridges dispensed to the patient.
Patients should be encouraged to read the information sheet carefully and to ask their physician and pharmacist about
the proper use of the product .
Patients must be advised to keep both used and unused cartridges out of the reach of children and pets.
Nicoderm Cq
Organisms Affected
Humans and other mammals