L-Nicotine
L-Nicotine Brand names, L-Nicotine Analogs
- Black Leaf
- Black Leaf 40
- Campbell's Nico-Soap
- Commit
- Destruxol Orchid Spray
- Emo-Nik
- Flux Maag
- Fumetobac
- Habitrol
- L-Nicotine
- Mach-Nic
- Niagara P.A. Dust
- Nic-Sal
- Nico-Dust
- Nico-Fume
- Nicocide
- Nicoderm
- Nicoderm Cq
- Nicorette
- Nicorette Plus
- Nicotin
- Nicotina
- Nicotine Alkaloid
- Nicotine Polacrilex
- Nicotrol
- Nicotrol Inhaler
- Nicotrol Ns
- Nikotin
- Nikotyna
- Ortho N-4 Dust
- Ortho N-5 Dust
- Prostep
- Tendust
- Tetrahydronicotyrine, Dl-
- XL All Insecticide
L-Nicotine Brand Names Mixture
- No information avaliable
L-Nicotine Chemical_Formula
C10H14N2
L-Nicotine RX_link
http://www.rxlist.com/cgi/generic2/nicotini.htm
L-Nicotine fda sheet
L-Nicotine msds (material safety sheet)
L-Nicotine Synthesis Reference
Pinner, Ber. 26, 294 (1893)
L-Nicotine Molecular Weight
162.232 g/mol
L-Nicotine Melting Point
-79 oC
L-Nicotine H2O Solubility
1 g/mL
L-Nicotine State
Liquid
L-Nicotine LogP
1.305
L-Nicotine Dosage Forms
Gum; Inhaler; Patch
L-Nicotine Indication
For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
L-Nicotine Pharmacology
Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia.
L-Nicotine Absorption
Absorption of nicotine through the buccal mucosa is relatively slow and the high and rapid rise followed by the decline in nicotine arterial plasma concentrations seen with cigarette smoking are not achieved with the inhaler. About 10% of absorbed nicotine is excreted unchanged in urine.
L-Nicotine side effects and Toxicity
Symptoms of overdose include nausea, abdominal pain, vomiting, diarrhea, diaphoresis, flushing, dizziness, disturbed hearing and vision, confusion, weakness, palpitations, altered respiration and hypotension. LD50= 24 mg/kg (orally in mice).
L-Nicotine Patient Information
A patient information sheet is included in the package of NICOTROL Inhaler cartridges dispensed to the patient. Patients should be encouraged to read the information sheet carefully and to ask their physician and pharmacist about the proper use of the product .
Patients must be advised to keep both used and unused cartridges out of the reach of children and pets.
L-Nicotine Organisms Affected
Humans and other mammals
