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Nicocide Brand names, Nicocide Analogs

Nicocide Brand Names Mixture

  • No information avaliable

Nicocide Chemical_Formula


Nicocide RX_link

Nicocide fda sheet

Nicocide FDA

Nicocide msds (material safety sheet)

Nicocide MSDS

Nicocide Synthesis Reference

Pinner, Ber. 26, 294 (1893)

Nicocide Molecular Weight

162.232 g/mol

Nicocide Melting Point

-79 oC

Nicocide H2O Solubility

1 g/mL

Nicocide State


Nicocide LogP


Nicocide Dosage Forms

Gum; Inhaler; Patch

Nicocide Indication

For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Nicocide Pharmacology

Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia.

Nicocide Absorption

Absorption of nicotine through the buccal mucosa is relatively slow and the high and rapid rise followed by the decline in nicotine arterial plasma concentrations seen with cigarette smoking are not achieved with the inhaler. About 10% of absorbed nicotine is excreted unchanged in urine.

Nicocide side effects and Toxicity

Symptoms of overdose include nausea, abdominal pain, vomiting, diarrhea, diaphoresis, flushing, dizziness, disturbed hearing and vision, confusion, weakness, palpitations, altered respiration and hypotension. LD50= 24 mg/kg (orally in mice).

Nicocide Patient Information

A patient information sheet is included in the package of NICOTROL Inhaler cartridges dispensed to the patient. Patients should be encouraged to read the information sheet carefully and to ask their physician and pharmacist about the proper use of the product .

Patients must be advised to keep both used and unused cartridges out of the reach of children and pets.

Nicocide Organisms Affected

Humans and other mammals