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Commit Brand names, Commit Analogs

Commit Brand Names Mixture

  • No information avaliable

Commit Chemical_Formula


Commit RX_link

Commit fda sheet

Commit FDA

Commit msds (material safety sheet)

Commit MSDS

Commit Synthesis Reference

Pinner, Ber. 26, 294 (1893)

Commit Molecular Weight

162.232 g/mol

Commit Melting Point

-79 oC

Commit H2O Solubility

1 g/mL

Commit State


Commit LogP


Commit Dosage Forms

Gum; Inhaler; Patch

Commit Indication

For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Commit Pharmacology

Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Nicotine exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Nicotine is a highly addictive substance. Nicotine also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Nicotine inhalers and patches are used to treat smoking withdrawl syndrome. Nicotine is classified as a stimulant of autonomic ganglia.

Commit Absorption

Absorption of nicotine through the buccal mucosa is relatively slow and the high and rapid rise followed by the decline in nicotine arterial plasma concentrations seen with cigarette smoking are not achieved with the inhaler. About 10% of absorbed nicotine is excreted unchanged in urine.

Commit side effects and Toxicity

Symptoms of overdose include nausea, abdominal pain, vomiting, diarrhea, diaphoresis, flushing, dizziness, disturbed hearing and vision, confusion, weakness, palpitations, altered respiration and hypotension. LD50= 24 mg/kg (orally in mice).

Commit Patient Information

A patient information sheet is included in the package of NICOTROL Inhaler cartridges dispensed to the patient. Patients should be encouraged to read the information sheet carefully and to ask their physician and pharmacist about the proper use of the product .

Patients must be advised to keep both used and unused cartridges out of the reach of children and pets.

Commit Organisms Affected

Humans and other mammals