Methazolamide
Methazolamide Brand names, Methazolamide Analogs
Methazolamide Brand Names Mixture
- No information avaliable
Methazolamide Chemical_Formula
C5H8N4O3S2
Methazolamide RX_link
http://www.rxlist.com/cgi/generic2/methaz.htm
Methazolamide fda sheet
Methazolamide msds (material safety sheet)
Methazolamide Synthesis Reference
Young, et al., J. Am. Chem. Soc. 78, 4649 (1956)
Methazolamide Molecular Weight
236.274 g/mol
Methazolamide Melting Point
213.5 oC
Methazolamide H2O Solubility
3500 mg/L
Methazolamide State
Solid
Methazolamide LogP
0.231
Methazolamide Dosage Forms
Tablet
Methazolamide Indication
For treatment of chronic open-angle glaucoma and acute angle-closure glaucoma
Methazolamide Pharmacology
Methazolamide is topical carbonic anhydrase inhibitor. Methazolamide is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers. Methazolamide is a sulfonamide derivative; however, it does not have any clinically significant antimicrobial properties. Although methazolamide achieves a high concentration in the cerebrospinal fluid, it is not-considered an effective anticonvulsant. Methazolamide has a weak and transient diuretic effect, therefore use results in an increase in urinary volume, with excretion of sodium, potassium and chloride.
Methazolamide Absorption
Methazolamide is well absorbed from the gastrointestinal tract.
Methazolamide side effects and Toxicity
Electrolyte imbalance, development of an acidotic state, and central nervous system effects might be expected to occur in the case of an overdose.
Methazolamide Patient Information
Methazolamide Organisms Affected
Humans and other mammals
