MZM
MZM Brand names, MZM Analogs
MZM Brand Names Mixture
- No information avaliable
MZM Chemical_Formula
C5H8N4O3S2
MZM RX_link
http://www.rxlist.com/cgi/generic2/methaz.htm
MZM fda sheet
MZM msds (material safety sheet)
MZM Synthesis Reference
Young, et al., J. Am. Chem. Soc. 78, 4649 (1956)
MZM Molecular Weight
236.274 g/mol
MZM Melting Point
213.5 oC
MZM H2O Solubility
3500 mg/L
MZM State
Solid
MZM LogP
0.231
MZM Dosage Forms
Tablet
MZM Indication
For treatment of chronic open-angle glaucoma and acute angle-closure glaucoma
MZM Pharmacology
Methazolamide is topical carbonic anhydrase inhibitor. Methazolamide is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers. Methazolamide is a sulfonamide derivative; however, it does not have any clinically significant antimicrobial properties. Although methazolamide achieves a high concentration in the cerebrospinal fluid, it is not-considered an effective anticonvulsant. Methazolamide has a weak and transient diuretic effect, therefore use results in an increase in urinary volume, with excretion of sodium, potassium and chloride.
MZM Absorption
Methazolamide is well absorbed from the gastrointestinal tract.
MZM side effects and Toxicity
Electrolyte imbalance, development of an acidotic state, and central nervous system effects might be expected to occur in the case of an overdose.
MZM Patient Information
MZM Organisms Affected
Humans and other mammals
